• Dr. Bill Rawls


    Dr. Rawls' groundbreaking approach to wellness comes from decades of practicing medicine, extensive research in alternative therapies, and firsthand experience helping thousands find their path to wellness. Dr. Rawls is a best-selling author, Medical Director and Co-Founder of Vital Plan, a holistic health company and Certified B Corporation.
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  • Pine Bark Extract (PBE)
    By Vital Plan
    Reviewed by Bill Rawls, MD
    Medical Director of Vital Plan

    Summary | What is it? | Benefits and How It Works | History & Traditional Use |
    How to Use and Dosing | Interactions | Precautions & Side Effects | References


    Common name: Pine bark extract
    Scientific name: Pinus spp.
    Other names: Masson pine bark, French maritime pine bark
    Location: Native to the temperate regions of the Northern Hemisphere
    Known for: Its high antioxidant content and fresh scent
    Part Used: Pine bark is used to make pine bark extract, but pine needles, resin, pollen, and seeds are also used for various medicinal preparations.
    Fun fact: There is a 4,600 year old bristlecone pine tree (Pinus longaeva) in Eastern California named Methuselah.1
    Good for: Cardiovascular system, immune support, antioxidant benefits, and skin health
    Key Properties & Actions: Antioxidant, anti-inflammatory, antimicrobial, antitumor, cardioprotective, hypotensive, vasodilator


    Pine bark extract is obtained from the bark of pine trees and contains powerful antioxidant compounds. This antioxidant activity helps to support a robust cardiovascular system and many other organs and systems of the body.

    What is Pine Bark Extract?

    Pine trees are well recognized for their ornamental and commercial value, but these familiar trees also possess impressive medicinal benefits.

    Pine trees are evergreen conifers that are native to the temperate regions of the Northern Hemisphere and grow across the globe. Pines are characterized by needle-like leaves and their bark tends to be thick and scaly.

    Pine bark extract is obtained from the bark of pines, most commonly French maritime pine and masson pine, Pinus pinaster and Pinus massoniana, respectively.

    upward view of  pine tree, close up to bark texture

    For many years, humans have extracted the bark of plants. Many well-known products have their origin from bark including salicylic acid which comes from the white willow tree and cinnamon which is the inner bark of an evergreen tree.

    Pine bark extract is rich in antioxidants, specifically proanthocyanidins, that can help support the cardiovascular system, the immune system, healthy skin, joints, and eyes.

    Benefits of Pine Bark Extract and How It Works

    Cardiovascular Protection

    The phytochemicals in pine bark extract have been found to improve the integrity of the entire vascular system.

    Increased oxidative stress can compromise the health and function of the cardiovascular system. Pine bark extract provides potent antioxidants that can fight free radicals that cause oxidative stress and protect blood vessels.2

    A 2020 animal study gave hypertensive rats a Korean red pine bark extract (Pinus densiflora) for 7 weeks and compared this group against a control group. The study found that the pine bark extract reduced blood pressure in the hypertensive rats.

    The authors of the study suggest that pine bark extract’s powerful antioxidant compounds can lower blood pressure by protecting tissues from damage and increasing nitric oxide, a vasodilator.

    Additionally, the pine bark extract inhibited angiotensin-converting enzyme (ACE), a naturally occurring enzyme in the human body that increases blood pressure.3

    A 2014 clinical pilot study investigated the effects of pine bark extract and gotu kola on subclinical arterial lesions in low-risk asymptomatic human subjects.

    The pine bark extract and gotu kola combination reduced plaque progression and oxidative stress. The authors state the results of this study justify larger studies to demonstrate the efficacy of these two plants in combination on subclinical atherosclerosis.4

    Improved Skin Appearance

    Although our skin is naturally equipped to manage the oxidative stress generated by solar UV radiation, this system can become less efficient as we age. Additionally, excessive sun exposure can accelerate skin aging. This often appears as hyperpigmented areas or “age spots”.5

    Pine bark extract can reduce hyperpigmentation and ameliorate the skin barrier function which is vital for protecting the body from external stressors such as microbes and retaining moisture and nutrients within the skin.

    Several studies have found the oral administration of pine bark extract to be helpful in improving the appearance of photodamaged skin.

    In a randomized 12 week open trial, healthy women younger than 60 who had age spots and other symptoms of photodamaged skin like pigmentation, roughness, wrinkles, and swelling, were given an orally administered pine bark extract.

    The study found that 71% of participants had improvement in age spots revealed by digital images.5

    pine bark needles growing from branch

    Immune Support

    Bark protects a tree or shrub from many threats, including free radicals, insects, and microbes. Not surprisingly,extracts from many tree and shrub barks (including pine bark) have remarkable protective properties that extend to the human immune system as well.

    A 2014 in vitro study found the resin-oil of the Pinus elliottii pine species to inhibit multi-drug resistant staph bacterial strains.6

    Beyond its antibacterial qualities, pine bark extract has demonstrated encouraging anticancer activity in vitro that merits further investigation.

    A 2016 in vitro study published in Cell Biology and Toxicology investigated the anticancer activity of pine bark extract from the Pinus radiata (Monterey Pine) species.

    The pine bark extract was able to induce potent cytotoxic effects in human breast cancer cells. The authors suggest that further studies are needed to explore the exact mechanism behind this anticancer activity.7

    Another in vitro study found that pine bark extract from Pinus massoniana exerted anti-tumor effects on ovarian cancer cells by inhibiting cell growth and inducing apoptosis.8

    Joint Health

    Though it’s more widely known for its cardiovascular benefits, pine bark extract also provides support for joint comfort and inflammation.

    A 2018 review published in the peer-reviewed Journal of Medicinal Food, examined the effects of a standardized pine bark extract (French Maritime) on mild osteoarthritis patients (OA).9

    Three clinical studies were reviewed that all showed highly significant improvement in symptoms of mild OA with no unwanted side effects. The authors state that the pine bark extract has sustained-release anti-inflammatory action due to antioxidant compounds within the plant.9

    Eye Health

    Pine bark extract’s powerful antioxidant properties can benefit many systems and organs of the body including the eyes.

    The eyes are susceptible to oxidative stress due to continuous exposure to solar ultraviolet light and other internal and external factors.

    Aging can also accelerate oxidative stress, contributing to the eye becoming pro-oxidant. Eyes in a pro-oxidant state can lead to ocular diseases like cataracts.

    In a 2017 animal study, researchers studied the effects of pine bark extract on cataract formation.

    The study showed that pine bark extract was able to prevent cataract formation in rats by protecting against oxidative stress and inhibiting breakdown of proteins and lens epithelial cells which are vital for maintaining the transparency of the lens.10

    History & Traditional Use

    Pine trees have been used as food and medicine for thousands of years. The pine needles, bark, resin, and pollen are all used for medicinal purposes.

    Some sources suggest that the use of pine bark for inflammation can be traced back to Hippocrates, the “Father of Medicine”, around 400 BC.11

    Path winding through a pine forest, Yosemite National Park, Sierra Nevada mountains, California

    Bark from Pinus pinaster, also known as European coastal pine, has been used for many years by the Native people of Quebec. During the winter of 1534, these Native people introduced a tea made from pine bark and pine needles to the French explorer Jacques Cartier. It is said that this tea saved Cartier and his crew from a bout of scurvy.11

    In Asia, the pine species Pinus densiflora is used as an herbal medicine for stroke, atherosclerosis, hypertension, and diabetes.12

    Masson pine, Pinus massoniana, is native to south and southwest China where its bark is used for inflammation and joint pain.

    How to Use and Dosing

    Pine bark extract is most commonly consumed as a capsule. Look for masson pine bark extract (Pinus massoniana) or French maritime pine bark extract (Pinus pinaster) that has been standardized to around 95% proanthocyanidins.

    General dosage for a pine bark extract standardized to 95% proanthocyanidins is 50-300 mg daily.

    For added antioxidant support, pine bark extract works well with turmeric, Japanese knotweed, glutathione, and L-theanine from green tea.

    For cardiovascular health, try combining pine bark extract with garlic, hawthorn, reishi mushroom, rhodiola, gotu kola, and Chinese salvia.


    There are no known interactions.

    Always check with your health care practitioner before use if you are taking medications. For more general education on potential interactions between herbs and medications, check out Dr. Bill Rawls’ article: Is it Safe to Take Herbs with My Medications?

    Precautions & Side effects

    Pine bark extract is generally well tolerated. Before taking pine bark extract, consult with your health care practitioner if you are pregnant or nursing

    Disclaimer: This information is intended only as general education and should not be substituted for professional medical advice. Any mentioned general dosage options, safety notices, or possible interactions with prescription drugs are for educational purposes only and must be considered in the context of each individual’s health situation and the quality and potency of the product being used. Use this information only as a reference in conjunction with the guidance of a qualified healthcare practitioner.

    The Cellular Wellness Solution

    Discover more in Dr. Bill Rawls’ new #1 Bestselling book: The Cellular Wellness Solution: Tap Into Your Full Health Potential with the Science-Backed Power of Herbs.

    An eye-opening and empowering book that the world needs right now: The Cellular Wellness Solution will fundamentally change how you think about herbs and the powerful role they play in cultivating wellness at the cellular level.”

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    Mark Hyman, MD
    Fourteen-time #1 New York Times Bestselling Author

    Want to See the Science? Check Out Our References Below.

    1. De La Forêt R. Pine Monograph. HerbMentor. https://herbmentor.learningherbs.com/herb/pine/
    2. Ohkita M, Kiso Y, Matsumura Y. Pharmacology in health foods: improvement of vascular endothelial function by French maritime pine bark extract (Flavangenol). J Pharmacol Sci. 2011;115(4):461-465. doi:10.1254/jphs.10r37fm
    3. Kim KJ, Hwang ES, Kim MJ, Park JH, Kim DO. Antihypertensive Effects of Polyphenolic Extract from Korean Red Pine (Pinus densiflora Sieb. et Zucc.) Bark in Spontaneously Hypertensive Rats. Antioxidants (Basel). 2020;9(4):333. Published 2020 Apr 19. doi:10.3390/antiox9040333
    4. Belcaro G, Dugall M, Hosoi M, et al. Pycnogenol® and Centella Asiatica for asymptomatic atherosclerosis progression. Int Angiol. 2014;33(1):20-26.
    5. Furumura M, Sato N, Kusaba N, Takagaki K, Nakayama J. Oral administration of French maritime pine bark extract (Flavangenol(®)) improves clinical symptoms in photoaged facial skin. Clin Interv Aging. 2012;7:275-286. doi:10.2147/CIA.S33165
    6. Leandro LF, Cardoso MJO, Silva SDC, et al. Antibacterial activity of Pinus elliottii and its major compound, dehydroabietic acid, against multidrug-resistant strains. J Med Microbiol. 2014;63(Pt 12):1649-1653. doi:10.1099/jmm.0.081711-0
    7. Venkatesan T, Choi YW, Mun SP, Kim YK. Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells. Cell Biol Toxicol. 2016;32(5):451-464. doi:10.1007/s10565-016-9346-9
    8. Liu J, Bai J, Jiang G, et al. Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration. PLoS One. 2015;10(11):e0142157. Published 2015 Nov 5. doi:10.1371/journal.pone.0142157
    9. Rohdewald PJ. Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. J Med Food. 2018;21(1):1-4. doi:10.1089/jmf.2017.0015
    10. Kim J, Choung SY. Pinus densiflora bark extract prevents selenite-induced cataract formation in the lens of Sprague Dawley rat pups. Mol Vis. 2017;23:638-648. Published 2017 Sep 11.
    11. Maimoona A, Naeem I, Saddiqe Z, Jameel K. A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract. J Ethnopharmacol. 2011;133(2):261-277. doi:10.1016/j.jep.2010.10.041
    12. Jiang Y, Han W, Shen T, Wang MH. Antioxidant Activity and Protection from DNA Damage by Water Extract from Pine (Pinus densiflora) Bark. Prev Nutr Food Sci. 2012;17(2):116-121. doi:10.3746/pnf.2012.17.2.116
    13. Engels G, Oeschler L. Pine. www.herbalgram.org. Published 2005. Accessed February 16, 2023. https://www.herbalgram.org/resources/herbalgram/issues/65/table-of-contents/article2756/
    14. Mármol I, Quero J, Jiménez-Moreno N, Rodríguez-Yoldi MJ, Ancín-Azpilicueta C. A systematic review of the potential uses of pine bark in food industry and health care. Trends in Food Science & Technology. 2019;88:558-566. doi:10.1016/j.tifs.2018.07.007

    *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your qualified healthcare provider before beginning any diet or program.
    About the Medical Director
    Dr. Bill Rawls
    Dr. Rawls is a licensed medical doctor in North Carolina and a leading expert in integrative health. He has extensive training in alternative therapies, and is the Medical Director of Vital Plan, a holistic health and herbal supplement company in Raleigh, NC.

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